I don't think sothey were both overwatch leaders so Ana and Gerard were probably good friends... So makes sense that Ana hates Amalie and says Gerard was dumb to fall for her
Ana and Reinhardt were a thing. She didnt love Gerard they were good friends like she and Jack were and Reyesbefore he became Reaper. Ana hates Widowmaker for so many reasons. Ana trained Widowmaker, she melded her into the sniper she is. And widowmaker is the one that took Anas eye, then she killed Gerard. Shes saying he was a fool for loving someone like Amelie.